CD25-expressing B-lymphocytes in Rheumatic Diseases

Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood

BACKGROUND We have shown that approximately 30% of human peripheral blood B-cells express CD25. B cells expressing CD25 display a mature phenotype belonging to the memory B-cell population and have a better proliferative and antigen-presenting capacity. The aim of the present study was to characterize the CD25-expressing subset of B cells in human cord blood. MATERIAL AND METHODS Mononuclear ...

Fasting and rheumatic diseases

Fasting is one of the important religious practices of Muslims, in which the individuals abstain from eating and drinking from dawn to sunset. Fasting is not obligatory or even not allowed, in case it causes health problems to the fasting individual. Rheumatic diseases are a major group of chronic diseases which can bring about numerous problems while fasting. The aim of this article is to revi...

B-cell-targeted therapy in rheumatic diseases

Impaired catecholaminergic signalling of B lymphocytes in patients with chronic rheumatic diseases.

OBJECTIVE To investigate further the influence of the autonomic nervous system on chronic rheumatic diseases. METHODS The density and affinity of beta2 adrenergic receptors (beta2R) on CD19+ lymphocytes in patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc), as well as intracellular cAMP levels in patients with RA and SLE, were determined....

Activated CD4+CD25+ T cells selectively kill B lymphocytes.

The suppressive capacity of naturally occurring mouse CD4+CD25+ T cells on T-cell activation has been well documented. The present study is focused on the interaction of CD4+CD25+ T cells and B cells. By coculturing preactivated CD4+CD25+ T cells with B cells in the presence of polyclonal B-cell activators, we found that B-cell proliferation was significantly suppressed. The suppression of B-ce...